Cefazolin Injection - Quick Guide for Administration

CEFAZOLIN 1G
Route	Dilution	Infusion Rate
Reconstitution	For IM & IV: Add 3 ml diluents (concentration produced ~ 286 mg/mL)  1
INTRAVENOUS INJECTION	After recon, further dilute in a minimum of 10 mL of sterile WFI 1	Inject solution slowly over a period of 3-5 minutes 1,2,4
INTRAVENOUS Infusion	After recon, further dilute 50-100 mL with diluent 1	Over 30 – 60 minutes 2
Intramuscular	Should be injected into a large muscle mass.1
DILUENT   &   Stability	AFTER  RECONSTITUTION Storage1 Diluent (Either one selection) 1 Room Temperature (25°C) Refrigerated (2-8°C) §  Sterile WFI §  Bacteriostatic WFI 12 hours 24 hours   AFTER FURTHER DILUTION Storage1 Room Temperature (25°C) Refrigerated (2-8°C) Diluent (Either one selection) 1,3 §  NS §  D5 §  D10 §  LR §  NSD5 §  D5+LR §  D5+ 0.45% NaCl §  D5+ 0.2% NaCl §  Ringer’s Solution §  Plasma-Lyte with D5 12 hours 24 hours
Remarks	·      Each gram Cefazolin contains 48.3 mg sodium.1,4 ·      DO NOT use reconstituted injection solution if there is any sign of turbidity. 1 ·      Do NOT freeze reconstituted cefazolin. 1 ·      Safety for use in premature infants and infants under one month has not been established. 1,4  However, a few neonatal dosage recommendations are available in literature.4 ·      Paediatric: ü  Maximum concentrations for peripheral administration are : 77 mg/mL in D5 ; 69 mg/ml in NS ; 138 mg/ml in sterile WFI.3,4 ü  Concentration recommended for INTERMITTENT INFUSION = 5-20 mg/mL4
References	1.    Product Leaflet (CEFAZOLIN-AFT ; Revised July 2018) 2.    Lexi-Comp Drug Info (Lexi-Comp®) Lexi-Drug. [Accessed on 21 October 2020] 3.    Micromedex Version v2.5b851 [Accessed 27 Oct 2020] 4.    The Teddy Bear Book: Pediatric Injectable Drugs, 10th Edi., 2013.

 Prepared by Syahmi, Edited by  J. Ho [04.11.2020]