Tuesday, October 27, 2020

Cefazolin Injection - Quick Guide for Administration

CEFAZOLIN 1G

Route

Dilution

Infusion Rate

Reconstitution

For IM & IV: Add 3 ml diluents (concentration produced ~ 286 mg/mL)  1

INTRAVENOUS INJECTION

After recon, further dilute in a minimum of 10 mL of sterile WFI 1

Inject solution slowly over a period of 3-5 minutes 1,2,4

INTRAVENOUS

Infusion

After recon, further dilute 50-100 mL with diluent 1

Over 30 – 60 minutes 2

Intramuscular

Should be injected into a large muscle mass.1

DILUENT

 

&

 

Stability

 

AFTER  RECONSTITUTION

Storage1

Diluent (Either one selection) 1

Room Temperature (25°C)

Refrigerated

(2-8°C)

§  Sterile WFI

§  Bacteriostatic WFI

12 hours

24 hours

 

AFTER FURTHER DILUTION

Storage1

Room Temperature (25°C)

Refrigerated (2-8°C)

Diluent (Either one selection) 1,3

§  NS

§  D5

§  D10

§  LR

§  NSD5

§  D5+LR

§  D5+ 0.45% NaCl

§  D5+ 0.2% NaCl

§  Ringer’s Solution

§  Plasma-Lyte with D5

12 hours

24 hours

 

Remarks

·      Each gram Cefazolin contains 48.3 mg sodium.1,4

·      DO NOT use reconstituted injection solution if there is any sign of turbidity. 1

·      Do NOT freeze reconstituted cefazolin. 1

·      Safety for use in premature infants and infants under one month has not been established. 1,4  However, a few neonatal dosage recommendations are available in literature.4

·      Paediatric:

ü  Maximum concentrations for peripheral administration are :

77 mg/mL in D5 ; 69 mg/ml in NS ; 138 mg/ml in sterile WFI.3,4

ü  Concentration recommended for INTERMITTENT INFUSION = 5-20 mg/mL4

References

1.    Product Leaflet (CEFAZOLIN-AFT ; Revised July 2018)

2.    Lexi-Comp Drug Info (Lexi-Comp®) Lexi-Drug. [Accessed on 21 October 2020]

3.    Micromedex Version v2.5b851 [Accessed 27 Oct 2020]

4.    The Teddy Bear Book: Pediatric Injectable Drugs, 10th Edi., 2013.

 Prepared by Syahmi, Edited by  J. Ho [04.11.2020]



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