Method of administration of methyprednisolone

Diluents:

• Dextrose 5% in water
• Normal Saline
• Dextrose 5% in 0.45% or 0.9% sodium chloride

Method of administration:

• Low dose ≤ 1.8mg/kg or ≤125mg/dose: IV push over 3-15mins
• Moderate dose: ≥2mg/kg or 250mg/dose: IV over 15-30mins
• High dose: 15mg/kg or ≥500mg/dose: IV over ≥30mins
• Doses > 15mg/kg or ≥1g: Administer over 1 hour
• Max concentration: 2.5-20 mg/ml

Additional information: 

• Administer at high dose IV push may lead to hypotension, cardiac arrhythmias, and cardiac arrest.

References:

      1.Lexicomp 20th edition

      2. Pzifer Drug Information leaflet