Rationale for Tazocin use in paediatric

Available Product: 

• Piperacillin/Tazobactam (4g/500mg)

MOH Blue Book Indication

• Febrile neutropenia, Lower respiratory tract infection, severe sepsis

Other guidelines:

• Hospital acquired pneumonia, septicaemia, complicated infections involving urinary tract or skin and soft tissues, complicated intra-abdominal infections, appendicitis, peritonitis

Spectrum

Dosing

Frank Shann

• 100mg/kg (based on piperacillin only)  TDS (<6 months) QID (>6 months); consider constant infusion for severe infection

BNF for children

• > 12 years use adult dosing
• 90mg/kg TDS-QID (max 4.5g QID)
• For complicated intra abdominal infection 112.5mg/kg (max 4.5g) TDS

Product Leaflet/ MOH Blue Book

• >50kg refere adult dosing
• Neutropenia: 80/ 10mg / kg QID, in combination with the appropriate dose of an aminoglycoside
• Abdominal infection: 100/12.5mg / kg TDS (product leaflet)

References:

1. Frank Shann
2. BNF for Children 2013
3. Product Information Leaflet
4. MOH Blue Book