|
Metoclopramide hydrochloride
|
- is a prokinetic agent that acts as a
cholinergic agonist and a dopamine antagonist
- No studies had a significant benefit in the treatment
of postoperative ileus
- Some data have shown that the drug may
actually worsen ileus
|
|
Erythromycin
|
- motilin receptor agonist that binds to
gastrointestinal smooth-muscle membrane receptors
- did not resolve postoperative ileus in patients
who underwent abdominal surgery
|
|
Octreotide
|
- analogue of somatostatin that is known to
inhibit the secretion of many gastrointestinal hormones
- octreotide therapy shortens the duration of
ileus in the small intestine and colon of dogs. However, clinical studies are
needed to prove its efficacy in humans
|
|
Laxatives
|
- potential
therapeutic option for treating POI, but no randomized, controlled trials
have assessed their utility
- found a
reduction in time to flatus and first bowel movement, as well as decreased
length of hospitalization
- Laxatives
have been used with other therapies after abdominal surgery in multimodal
rehabilitation studies, with promising results
|
|
Glycerin Enema
|
- Osmotic dehydrating agent which increases osmotic pressure; draws
fluid into colon and thus stimulates evacuation
- Cleansing enema is contraindicated in patients with fecal stones,
rectal obstruction by tumor or rectal prolapse, active coronary heart
disease, and in comatose or noncompliant patients
|
|
Fleet
|
- use of Fleet Enema (phospho-soda) is forbidden due to the danger of
hyperphosphatemia and phosphate nephropathy.
|
|
Gum chewing
|
- patients chewed gum 3 times a day starting
postoperative day 1 until oral intake
- related to the effects of sham feeding.
|
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.