Product: Intragam P (3g/50ml)
Dilution:
- Can be infused undiluted
- Maybe diluted with up to 2 parts of 0.9% saline or 5% glucose
Administration:
- Allow product to warm to room temperature
- Use a separate IV line from other IV fluids or medications. If primary line is used, flush with saline prior to administration
- Initial, infuse slower at 1ml/min for 15minutes
- If no reactions, the infusion rate can be gradually increased to a maximum of 3-4ml/min
Consideration for infusion rate:
- Rate should be reduced in elderly and patients with pre-existing renal conditions
- Too rapid infusions can cause flushing and changes in heart rate and blood pressure
- Slow the rate of infusion or stop infusion (5-10minutes) in patients who develop fever, chills, nausea and vomiting until symptoms subside. Resume infusion at a rate which is tolerated by the patient
Contraindication
- True anaphylactic reaction to IVIG
Precautions
- Prolonged administration (>6hours)at higher doses (>0.4g/kg) may result in thrombophlebitis at infusion site
- Aseptic Meningitis Syndrome has been reported. Usually begin within several hours to 2 days after initiation. Characterised by signs such as severe headache, nausea, drowsiness, fever, photophobia and painful eye movement.
- High risk of acute renal failure: above 65 years, volume depletion, sepsis, DM, pre-existing renal insufficiency, concomitant nephrotoxic drugs
Monitoring
- Serum creatinine (to evaluate for changes in renal function)
- complete blood count with differential (to evaluate for neutropenia and anemia) are also suggested
- mild-moderate elevation in LFT has been seen
- monitor for any reactions, which may be acute or delayed.
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.