- There are no drugs licensed for intrajejunal administration in the UK and little data on absorpion of drugs via this route.
- Other routes or alternative methods of treatment should therefore be sought wherever possible.
- Clinical response and drug levels should be monitored as a guide to treatment success
- However, based on several information, Paracetamol has a good absorption via this route.
Recommendations:
- Suppositories or injection can be considered useful alternatives
- As not many specific references exists for administration of drugs via Gastrojujenal stoma, recommendations is extrapolated from intrajejunal drug administration.
- Paracetamol is absorbed rapidly following oral administration. Administration into the jejunum achieves similar plasma concentration to oral administration
- Use tablets dispersed in 50 mL of water (for adults) for intragastric or intrajejunal administration. If the sodium content is problematic, use the liquid formulation.
- if administering intrajejunally, dilute with at least an equal quantity of water to reduce osmolarity and viscosity.
Administration considerations:
- Sterile water should be used to flush jejunostomy tubes and disperse tablets
- Use disperible tablets or finely crushed tablets dispersed in water as an alternative to liquid formulations
- Only where a drug has been shown to be compatible with enteral feed may a liquid preparation be mixed with feeding solution to reduce osmolality. In practice there is little data regarding compatibility with feeds and most feed manufacturers do not recommend this
- Rinse the measure with 10–20 mL of water and administer this also to ensure that the total dose. is given. Finally, flush with the recommended volume of water.
- Handbook of Drug Administration via Entereal Feeding Tubes
- Guidlines for the Administration of Drugs Through Enteral Feeeding Tubes (Devoid/awaiting newer recomendations)
- http://palliativedrugs.com/download/appendix10.pdf
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.