Dose Equivalence: Cloxacillin, Flucloxacillin, Oxacillin
Effectiveness
- Cloxacillin, Dicloxacillin and Flucloxacillin are considered comparable and have similar dose recommendations
- Oxacillin and Nafcillin are comparable in effectiveness and indication, however differs in dosing regimen
- example for MSSA
- Cloxacillin or flucloxacillin or dicloxacillin 25mg/kg up to 1g q6h
- Nafcillin or oxacillin 50mg/kg up to 2g q4h
Side Effects
- Flucloxacillin is reported to have higher, though rare, incidence of severe hepatic adverse effects than dicloxacillin, but a lower incidence of renal adverse effect
Pharmacokinetic
- flucloxacillin had a significantly longer serum elimination half-life
- extent of binding of flucloxacillin to the protein of human serum was
similar to that of oxacillin and cloxacillin and less than that of
dicloxacillin
Reference:
- Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006
- www.antimicrobe.org
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820086/
- https://www.nps.org.au/australian-prescriber/articles/what-to-use-instead-of-flucloxacillin
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