Duolin Respules
Availability:
- Ipratropium Bromide 0.5mg & salbutamol 2.5mg
- Dosage (adults & > 12 years)
- 1 respule 3-4 times daily
- One unit dose (respule) provides prompt relief in most cases.
- In severe cases, if an attack has not been relieved by one respule, two respules may be required
Administration
- respules should be used undiluted.
Pharmacokinetic
- For inhaled ipratropium is minimal, maximal responses usually develop over 30 to 90 minutes, lasting for four to six hours.
- The elimination half-life of ipratropium is approximately 3 to 4 hours after inhalation.
For Salbutamol significant bronchodilation occurs within minutes of inhalation of a therapeutic dose, persisting for three to four hours.
- The elimination half-life of salbutamol is estimated to range from 4 to 6 hours.
Reference:
- Duolin Respule Product Information Leaflet
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