Rationale:
- Budesonide and beclometasone dipropionate are considered equivalent on a microgram for microgram basis (1:1 dose ratio).
- However, the type of hydrofluoroalkane (HFA)-propelled beclometasone dipropionate (pMDI) (Qvar, IVAX) (available in Hospital Keningau) delivers beclometasone dipropionate in extra fine particles so that more is deposited in the lungs, leading to a 2:1 dose ratio with the CFC budesonide/beclometasone dipropionate devices
- Half the dose of fluticasone propionate, mometasone furoate or ciclesonide in micrograms is equivalent to a given dose of budesonide/beclometasone dipropionate (2:1 dose ratio).
References:
- GINA 2017
- Drug Information Leaflet
- https://www.nice.org.uk/guidance/ta138/chapter/3-the-technologies
- http://www.bpac.org.nz/2017/ics.aspx
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