- Experimental and clinical have strongly indicated that older antihypertensive drugs exert detrimental effects on erectile function while newer agents exert either neutral or even beneficial effects.
- Accumulating data indicate that antihypertensive drug therapy is associated with erectile dysfunction, that antihypertensive drugs have divergent effects on erectile function which is either
b) Neutral (calcium antagonists, ACE
inhibitors)
c)
Potentially beneficial
(angiotensin receptor blockers, nebivolol)
- Older antihypertensive drugs (diuretics and beta-blockers) are not ideal candidates for these patients due to their detrimental effects on erectile function, and should be used only if they are absolutely indicated.
- In case more than one class is indicated for an individual patient, the choice of an ARB should be considered.
- Switching from a drug with negative to a drug with positive effects on erectile function seems to be beneficial in hypertensive patients with erectile dysfunction.
Choice of ARB in Erectile Dysfunction
Losartan |
|
Irbesartan |
|
Valsartan |
|
- Doumas M, Boutari C, Viigimaa M. (2016) Arterial Hypertension & Erectile Dysfucntion : An Under-Recognised Duo. European Society of Cardiology. Retrieved from https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-14/arterial-hypertension-and-erectile-dysfunction-an-under-recognized-duo
- Dézsi, C. A. (2016). The Different Therapeutic Choices with ARBs. Which One to Give? When? Why? American Journal of Cardiovascular Drugs, 16(4), 255–266. http://doi.org/10.1007/s40256-016-0165-4
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