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Monday, August 29, 2016

SC Humalog Mix 50 Dosing & Dose Adjustment


Dosing Strategy


Patient
Dose
Frequency
Ref
Insulin naïve patient
5 units
BD (Breakfast & Dinner)
Product brochure
Titration : every 3-4 days based on premeal BG to acheieve BG <6.1mmol/L
Converting from low mix twice daily
1/3 units from current dose
TDS
( Breakfast, Lunch & Dinner)
Converting from low mix three times daily
(Twice daily Humalog Mix 50 & Once Daily Humalog Mix 25)
1/3 Humalog Mix50 (Breatkfast & Lunch)
1/3 Humalog Mix25 (Dinner)
For any diabetic population
5 to 10 units once or twice daily
(prebreakfast and/or presupper).
Titrate : 1 unit everyday until blood glucose reached target level
Diabetec.ca
Type 1 /Type 2 patient
Type 1 : 0.3-1U/kg/day in divided doses
Type 2 : 0.5-1.5U/kg/day
Tarascon Pharmacopoeia 2014


Dose Adjustment 


Average glucose before meal (mmol/L)
Change in insulin dose
Ref
<4.4
-2
Product brochure
4.4-6.1
0
6.1-7.7
+2
7.7-11.1
+4

References: 
  1. Product Brochure
  2. http://guidelines.diabetes.ca/Browse/Appendices/Appendix
  3. Eli Lilly Spokesperson 
  4. http://guidelines.diabetes.ca/CDACPG_resources/Insulin_Prescription_May_5_2014.pdf

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