Paraquat Poisoning : Fuller’s Earth

• Fuller’s Earth is a calcium montmorillonite and it has been used as one of the treatment in Paraquat Poisoning
• The mode of action is by tightly binding paraquat to the clay in the formulation, which takes place in thegastrointestinal tract and facilitates elimination in the feces.
• Dosing and dilution of Fuller’s Earth :
• Dosage form : 30% suspension
• Recommended dose : 100-150 g for adults or 2 g/kg body weight in children
• There is also some evidences showed the difference of concentration of Fuller’s Earth used in paraquat poisoning:
• Dosage form : 15% suspension
• Recommended dose : 100-150 g for adults or 2 g/kg body weight in children

HUSM FORMULARY

• Dosage Form: Suspension 30% Fuller’s Earth
• Recommended Dose: 300 ml of 30% Fuller’s Earth suspension every 2-4 hrs for several days.

DEPARTMENT Of MEDICAL SCIENCES, MINISTRY OF PUBLIC HEALTH THAILAND, 2005

• Dosage and administration: 200-500ml of 30% Fuller's Earth suspension every 2 hours for 3 doses, in association with 5% w/v magnesium sulphate or mannitol to promote diarrhea and empty the gut.

Reference

1. William N.R.  2007. Environmental and Occupational Medicine 4^th Edition, Wolters Kluwer health /Lippincot Williams & Wilkins, Philadelphia. 1834pp
2. http://www.kck.usm.my/husm/pharmacy/formulary/
3. http://paraquat.com/sites/default/files/PQ%20Booklet%20Rev8%20final%201600212.pdf
4. http://dmsc2.dmsc.moph.go.th/webroot/drug/products/pdf/antidotesComplete.pdf