- Metformin is an effective hypoglycaemic agent considered as first line therapy in people with type 2 diabetes.
- Based on Malaysian Adverse Drug Reaction (ADR) database, there are reports of tinnitus following use of metformin.
- WHO ADR database also revealed 51 reports pertaining tinnitus linked to metformin.
- Higher dose and longer duration of metformin use increases the risk for vitamin B12 deficiency in people with diabetes.
- Consequences of clinically important decreases in vitamin B12, such as macrocytic anaemia, neuropathy and mental changes, can be profound.
Signs and
symptoms of vitamin B12 deficiency
- Neurologic – difficulty walking, loss of vibratory sense, impaired sense of touch, peripheral neuropathy
- Psychiatric – irritability, personality changes, depression, psychosis, mild memory impairment
- Cardiovascular – possible increased risk of myocardial infarction and stroke, palpitation
- Aneorexia, mild weight loss diarrhoea, atrophic glossitis
- Urologic – difficulty in urination
- Dyspnoea
- VertigoTinnitus
- http://npra.moh.gov.my/images/Publications/Newsletter_MADRAC_Bulletin/Bulletin-MADRAC-August2014.pdf
- http://www.webstercare.com.au/files/wcconteduoct13.pdf
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.