Breastfeeding recommendations for Daflon
Manufacturers recommendations:
- In the absence of data concerning the
diffusion into breast milk,breastfeeding is not
recommended during treatment
Factors to Consider during Dosing:
- Expression into breastmilk (in rats):
- passage into breast milk was
assessed as 1% of
the dose administered to the mother
- Volume of distribution is 60L.
- the higher volume
distribution means the lesser tendency to stay in the blood and will distribute
to other body fluid
- Half life: 26-43hours.
- Thus it takes about 1-2 days to
achieve 50% of drug level in blood.
- Some recommendations is to wait about 7-10
days (6-7 half life) before starting to breastfeed.
- Monitoring parameter:
- based on pregnancy information in
rat/mice, no teratogenicity was seen.
- Thus no information of factors to monitor
References:
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