For renal impairment patient with SrCr<30mL/min
and those receiving hemodialysis:
- no changes for isoniazid and rifampicin
- Pyrazinamide (25-30mg/kg) and Ethambutol (15-25mg/kg) changed to three times per week administration due to significant renal excretion of both drugs.
- Antituberculosis drug should be given after hemodialysis to prevent drug loss.
References:
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