Midazolam
|
Propofol
|
|
USE
|
·
sedation, amnesia,
·
anxiolysis;
·
no analgesia
·
useful for many types of procedures; can
combine with an analgesic
|
·
sedation
·
mild antiemetic effect
·
use for intubation, brief procedures (may
redose for longer procedures)
|
ADVANTAGES
|
·
short duration
·
[onset: 5-15 min (20 with PR)]
·
minimal cardiovascular effects
|
·
very rapid return to baseline after
discontinuing use
|
DISADVANTAGES
|
·
respiratory depression
·
(rate-dependent; give IV slowly),
·
duration may be prolonged with oral doses
> 0.5 mg/kg
|
·
limited experience in children, use with
caution
·
cost
|
·
Both agents are
comparable in terms of EFFICACY and SIDE EFFECT
|
REFERENCES:
- Conscious sedation in interventional radiology: A comparison of Propofol versus Midazolam http://www.sedationconsulting.com/about/principals/143-propofol-vs-midazolam-article
- UNIVERSITY OF VIRGINIA CHILDREN'S HOSPITAL PEDIATRIC SEDATION FOR DIAGNOSTIC AND THERAPEUTIC PROCEDURES
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