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Monday, March 23, 2015

Comparison between Midazolam and Propofol for Sedation


Midazolam
Propofol
USE
·         sedation, amnesia,
·         anxiolysis;
·         no analgesia
·         useful for many types of procedures; can combine with an analgesic

·         sedation
·         mild antiemetic effect
·         use for intubation, brief procedures (may redose for longer procedures)
ADVANTAGES
·         short duration
·         [onset: 5-15 min (20 with PR)]

·         minimal cardiovascular effects
·         very rapid return to baseline after discontinuing use

DISADVANTAGES
·         respiratory depression
·         (rate-dependent; give IV slowly),
·         duration may be prolonged with oral doses > 0.5 mg/kg
·         limited experience in children, use with caution
·         cost

·         Both agents are comparable in terms of EFFICACY and SIDE EFFECT

REFERENCES:
  1. Conscious sedation in interventional radiology: A comparison of Propofol versus Midazolam http://www.sedationconsulting.com/about/principals/143-propofol-vs-midazolam-article
  2. UNIVERSITY OF VIRGINIA CHILDREN'S HOSPITAL PEDIATRIC SEDATION FOR DIAGNOSTIC AND THERAPEUTIC PROCEDURES

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