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Thursday, March 5, 2015

Comparison of pneumococcal conjugate vaccine (PCV13) and pneumococcal polysaccharide vaccine (PPSV 23) administration



PCV 13
PPSV 23
Serotypes
13
(1,3,4,5,6A, 6B,7F, 9V, 14, 18C, 19A, 19F, 23F)
23
(1,2,3,4,5,6B, 7F,8, 9N, 9V, 10A, 11A, 12F,14, 15B, 17F,18C, 19A, 19F, 29, 22F, 23F,33F)
Indication
Children < 5 years old
Adults ≥ 65 years old
19-64 years old with medical conditions
Children ≥ 2 years with medical conditions
Adults ≥ 65 years old
19-64 who smoke cigarette and asthma

Medical conditions
√ Immunocompromisingconditions
√ Certain immunocompetent conditions (except chronic heart disease, chronic lung disease, diabetes mellitus, alcoholism, chronic liver disease and cigarette smoking)
√ Functional or anatomic asplenia

√ Immunocompromising condition
√ Immunocompetent condition
√ Functional or anatomic asplenia


Repeat dose
No
Yes. Repeat at least 5 years after the first dose for person aged 19-64 years with medical conditions (except immunocompetent person)
Pregnancy
No recommendation
Recommended if some other risk factor is present)
Recommended intervals for PCV13 and PPSV 23 for adults aged  65 years old 

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