- Folate is a water-soluble B vitamin
- Absorption at proximal part of small intestine
- About 85% of supplemental folic acid, when taken with food, is bioavailable
- When consumed without food, nearly 100% of supplemental folic acid is bioavailable
People with alcohol dependence
- People with alcohol dependence frequently have poor-quality diets that contain insufficient amounts of folate.
- Moreover, alcohol interferes with folate absorption and metabolism and accelerates its breakdown
- Even moderate alcohol consumption of 240 ml (8 fluid ounces) red wine per day or 80 ml (2.7 fluid ounces) vodka per day for 2 weeks can significantly decrease serum folate concentrations in healthy men
People with malabsorptive disorders
- tropical sprue, celiac disease, and inflammatory bowel disease—might have lower folate absorption than people without these disorders
- Diminished gastric acid secretion associated with atrophic gastritis, gastric surgery, and other conditions can also reduce folate absorption
Reference
- Lexicomp
- http://ods.od.nih.gov/factsheets/Folate-HealthProfessional/
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