Infection/Condition
and Likely Organism
|
Preferred
treatment
|
Alternative
treatment
|
Hansen’s Disease
(Leprosy)
Mycobacterium
Leprae
|
Paucibacillary
Rifampicin 600mg PO monthly
(supervised)
PLUS
Dapsone 100mg PO q24h
Duration: 6 months
(Completion of 6 doses within 9 months)
Surveillance: 5 years
Multibacillary
Rifampicin 600mg PO monthly
PLUS
Clofazimine 300mg PO monthly
PLUS
Dapsone 100mg PO q24h
PLUS
Clofazimine 50mg PO q24h
Duration: 1 year (if initial BI˂4) or 2
years (if BI≥4)
Completion of 12 doses within 18 months
(BI<4)
Completion of 24 doses within 36 months (
BI≥4)
Surveillance:
15 years
|
Bacterial
resistance or hypersensitivity to first line
Can be substituted with one of the
following:
Minocycline 100mg PO q24h
OR
Ofloxacin 400mg PO q24h
OR
Clarithromycin 500mg PO q24h
OR
Ethionamide
250mg PO q24h
|
Hansen’s Disease
(Leprosy) in HIV
|
Same as non HIV patients
|
Same as non HIV patients
|
* Second line can only be
initiated by a dermatologist
REFERENCE:
National Antibiotic Guideline 2014
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