- First line treatment for PCP involves bactrim which has a major interaction with the first line treatment of toxoplasmosis which uses folinic acid
- Interaction between folinic acid and bactrim
- Treatment failure and excess mortality were observed when trimethoprim-sulfamethoxazole was used concomitantly with leucovorin for the treatment of HIV positive patients with Pneumocystis jiroveci pneumonia in a randomized placebo controlled trial.
- Co-administration of trimethoprim- sulfamethoxazole and leucovorin during treatment of Pneumocystis jiroveci pneumonia should be avoided.
References:
- http://www.drugs.com/disease-interactions/sulfamethoxazole-trimethoprim,bactrim.html
- http://www.rxlist.com/bactrim-drug/warnings-precautions.htm
- LEXICOMP
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