Pabrinex (parentrovite) duration of usage based on indicatons

Treatment of acute Wernicke-Korsakoff syndrome

• Two pairs of Pabrinex 5mL ampoules should be administered three times daily for two days. 
• If there is no clinical response after two days (six doses), treatment should be discontinued. 
• If clinical improvement is seen the contents of one pair of 5mL Pabrinex ampoules should then be administered three times daily for a further three days or for as long as clinical improvement continues.

High risk of Wernicke-Korsakoff syndrome. 

• One pair of Pabrinex 5mL ampoules administered three times daily for two days. 
• Following the initial intravenous loading dose, oral supplementation should begin with thiamine 100mg three times daily.
• This should be reviewed prior to discharge.

Rapid therapy of severe depletion or malabsorption of water soluble vitamins B and C, particularly in alcoholism

• 2 to 3 pairs of 5ml ampoules (1 pair = ampoule 1 + ampoule 2) diluted with 50ml to 100ml of infusion solution and injected over 30 minutes at intervals decided by your doctor (typically every 8 hours).

Psychosis following unconsciousness from a narcotic drug (narcosis) or electroconvulsive therapy, or poisoning from infection

• 10ml of the mixed vials (1 pair) injected twice daily for up to 7 days.

Haemodialysis patients

• 10ml of the mixed vials (1 pair) injected at the end of dialysis, once every 2 weeks.  

 Refeeding syndrome

• Pabrinex one to two pairs once to three times daily for 3 to 5 days (use the higher more frequent dose for chronic alcohol abusers.

REFERENCE

NHS Grampian

(http://www.nhsgrampian.com/grampianfoi/files/VitSupAC_503_1111.pdf)

Intensive Care Society Of Ireland 

(http://www.criticalcarenutrition.com/docs/BOB/ENPNGuideline.pdf)

Beaumont Hospital's Intensive Care Unit's

(http://www.criticalcarenutrition.com/docs/BOB/BeaumontGuidelines.pdf

Product Leaflet

BNF