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Tuesday, June 16, 2015

Pharmacological Treatment For Venous Ulcer

Available products in HKGU
Generic  name
Brand name
Acetylsalicylic acid 300mg
Uniaspirin

Treatment for venous ulcer
Generic name
Brand name
Dose & Frequency
Notes
Pentoxifylline 400mg
Trental
400mg TDS
Up to 6 months
Acetylsalicylic acid 300mg
Aspirin
300mg  OD
-

*Other treatment options (there is insufficient evidence to recommend its use):
  • Micronized purified flavonoid fraction
  • Mesoglycan
  • Zinc (oral)
  • Iloprost
REASONING
Pentoxifylline
  • Inhibitor of platelet aggregation
  • Reduces blood viscosity and, in turn, improves microcirculation
Aspirin
  • Increase ulcer healing time and reduce ulcer size
  • There is insufficient evidence on which to base a recommendation for aspirinin chronic venous leg ulcer
REFERENCE:
American Family Physician (http://www.aafp.org/afp/2010/0415/p989.html)
SIGN Guidelines (http://www.sign.ac.uk/pdf/sign120.pdf)

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