Hyperthyroidism
- Increased sensitivity to warfarin
- The mechanism may be that thyroxine increases the affinity of warfarin for receptor sites in the liver, leading to decreased production of clotting factors
- Another mechanism may be increased catabolism of vitamin K dependent clotting factors
- Decreased response to warfarin
- The mechanism may be decreased catabolism of vitamin K dependent clotting factors
- Decrease the anticoagulant effect of warfarin by either by increasing its metabolism or indirectly by interfering with absorption
- Increase anticoagulant effect
- Increasing thyroid hormone levels can increase sensitivity to warfarin which may increase the risk of bleeding
- http://www.medscape.com/viewarticle/410539_3
- http://www.aafp.org/afp/2000/1115/p2318.html
- http://www.inronline.net/index.php/information/179-2/drug-interactions/
- http://www.rxlist.com/drug-interactions/propylthiouracil-oral-and-warfarin-oral-interaction.htm
- http://www.rxlist.com/drug-interactions/levothyroxine-oral-and-warfarin-oral-interaction.htm
- http://www.bpac.org.nz/BPJ/2007/April/warfarin.aspx
- LEXICOMP
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